Leaf extract Of Indian Plant Could be Effective in Preventing Hepatic Cancer
Approximately three quarters of the container of liver cancer are father in Southeast Asia, including China, Hong Kong, Taiwan, Korea, India, and Japan.
The closeness of liver cancer in Southeast Asia and sub-Saharan Africa is greater than 20 cases per 100,000 population. Moreover, recent counsel show the frequency of liver cancer in the U.S.
With the increasing bias in the prevalence of cancers in our country, biomedical research directed at early detection and diagnosis, prognosis and survival, as well as forestalling of progression of malignancy, is of prime importance.
The point of cancer chemoprevention is to circumvent the development and course of malignant cells through the use of non-cytotoxic nutrients, herbal preparations a groundwork everyday shrub products, and or pharmacological agents.
Encouraging dietary intake with herbal supplements may therefore be an effective strategy to limit DNA lesions and organic impairment leading to cancers and other chronic degenerative diseases. A analysis team led close to Prof.
Malay Chatterjee from Jadavpur University investigated the salient chemopreventive mechanisms of Acanthus ilicifolius in an in vivo tumor-transplanted murine model. A. ilicifolius, popularly known as Harkach Kanta is distributed generally throughout the mangroves of India, including Sunderbans in West Bengal, west coasts, and the Andamans, and in other Asian countries like Singhal, Burma, China, Thailand etc.
The end result showed the aqueous leaf extract (ALE) of the plant was substantially efficacious in preventing hepatic DNA alterations and sister-chromatid exchanges (a type of chromosomal damage) in tumor-bearing mice.
The study further demonstrated that ALE handling of was able to limit liver metallothionein expression, a potential marker championing cell proliferation, and lengthen the mean survival of animals to a significant extent. The findings suggest that A. This check from Prof.
Chatterjees laboratory opens up a encouraging avenue in cancer chemoprevention with the practice of aboriginal plants. The results obtained from this in vivo study seem interesting and encouraging. Lack of toxicity favors further preclinical evaluation of A.
Elucidation of its anticarcinogenic mechanisms of action at the intricate molecular circuits, and isolation and characterization of its active principles, will provide a better compassionate of the anti-cancer chemoprevention procedure of A.
Whether these studies are found to be really functional, we will have the beginning of a new chemoprevention program with herbal supplements that could have the broadest implications for the well-being of society. Journal reference: Chakraborty T, Bhuniya D, Chatterjee M, Rahaman M, Singha D, Chatterjee BN, Datta S, Rana A, Samanta K, Srivastawa S, Maitra SK, Chatterjee M. Acanthus ilicifolius plant extract prevents DNA alterations in a transplantable Ehrlich ascites carcinoma-bearing murine model.
Universe J Gastroenterol 2007; 13(48): 6538-6548 http: 1007-9327 13 6538.asp Adapted from fabric provided by World Journal of Gastroenterology, via EurekAlert!, AAAS. Mail to a friend Print Article Permanent link: 1515 1 Leaf-extract-Of-Indian-Plant-Could-be-Effective-in-Preventing-Hepatic-Cancer Comments No Comments Found.
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