Hormonal dietary end-piece might promote prostate cancer progression

Public release date: 15-Jan-2008 E-mail Article Contact: Erin Prather Stafford erin.pratherstafford utsouthwestern.edu 214-648-3404 UT Southwestern Medical Centre Hormonal dietary supplements might promote prostate cancer progression Drs. Click here for more information. DALLAS - Jan.

Doctor of medicine want to ask their patients not only about the recipe drugs they may be taking, on the contrary - perhaps even more importantly - about the over-the-counter drugs and supplements, which may have a deep impact on certain trim conditions," said Dr.

Claus Roehrborn, chairman of urology at UT Southwestern and one of the study"s authors. The researchers began their investigation when two patients being seen by UT Southwestern doctors developed aggressive prostate cancer within months of starting daily consumption of the same dietary supplement.

Both men purchased the duplicate product, one to develop stronger muscles and augment procreative performance, the other to gain muscle. Dr. They begin that the product"s label listed part that were not present, misrepresented the concentrations of the ingredients present and failed to list all the steroid hormones contained in the product.

Hormone analysis revealed that the supplement contained testosterone and estradiol, a sex hormone. Researchers then tested the effect of the product on human prostate cancer-cell lines. The result proved to be a more potent stimulator of cancer-cell growth than testosterone.

Additionally, attempts to barricade the cancer-cell growth with increasing concentrations of the anti-cancer drug bicalutamide proved to be futile. Bicalutamide is an oral nonsteroidal anti-androgen worn to manage prostate cancer," Dr.

Shariat said. The fact that this appendix caused the drug to be less effective is very troubling." Based on the clinical data and cell culture experiments, the researchers filed an adverse event report with the Food and Drug Administration.

The authority agency in turn issued a warning letter to the manufacturers, which led to the removal of the product from the market. The researchers say expanded research is needed to define the mechanism, safety and efficacy of common herbal and hormone dietary supplements. For most supplements efficacy is not established in randomized, controlled trials.

What is worse, cover is regularly equally inadequately established," said Dr. Roehrborn, who manages the Sarah M. Charles E. Seay Center championing Pediatric Urology. An estimated 42 percent to 69 percent of U.S.

34.4 billion, according to published reports cited in the study. Individuals often use supplements because they affirm these natural products are safe and drug-free. The traffic of androgenic steroids is exponentially increasing.

In 2004, U.S. 425 million. Given that testosterone supplements are in high demand, there is significant concern that supplements, in addition to the one we evaluated, may pose an urgent human health risk," Dr. Researchers from Baylor College of Medicine in Houston also contributed to the research. Visit http: UT Southwestern"s clinical services in prostate cancer.

Claus Roehrborn - http:

From http://eurekalert.org/pub_releases/2008-01/usmc-hds011108.php