Approximately three quarters of the container of liver cancer are father in Southeast Asia, including China, Hong Kong, Taiwan, Korea, India, and Japan.

The closeness of liver cancer in Southeast Asia and sub-Saharan Africa is greater than 20 cases per 100,000 population. Moreover, recent counsel show the frequency of liver cancer in the U.S.

With the increasing bias in the prevalence of cancers in our country, biomedical research directed at early detection and diagnosis, prognosis and survival, as well as forestalling of progression of malignancy, is of prime importance.

The point of cancer chemoprevention is to circumvent the development and course of malignant cells through the use of non-cytotoxic nutrients, herbal preparations a groundwork everyday shrub products, and or pharmacological agents.

Encouraging dietary intake with herbal supplements may therefore be an effective strategy to limit DNA lesions and organic impairment leading to cancers and other chronic degenerative diseases. A analysis team led close to Prof.

Malay Chatterjee from Jadavpur University investigated the salient chemopreventive mechanisms of Acanthus ilicifolius in an in vivo tumor-transplanted murine model. A. ilicifolius, popularly known as Harkach Kanta is distributed generally throughout the mangroves of India, including Sunderbans in West Bengal, west coasts, and the Andamans, and in other Asian countries like Singhal, Burma, China, Thailand etc.

The end result showed the aqueous leaf extract (ALE) of the plant was substantially efficacious in preventing hepatic DNA alterations and sister-chromatid exchanges (a type of chromosomal damage) in tumor-bearing mice.

The study further demonstrated that ALE handling of was able to limit liver metallothionein expression, a potential marker championing cell proliferation, and lengthen the mean survival of animals to a significant extent. The findings suggest that A. This check from Prof.

Chatterjees laboratory opens up a encouraging avenue in cancer chemoprevention with the practice of aboriginal plants. The results obtained from this in vivo study seem interesting and encouraging. Lack of toxicity favors further preclinical evaluation of A.

Elucidation of its anticarcinogenic mechanisms of action at the intricate molecular circuits, and isolation and characterization of its active principles, will provide a better compassionate of the anti-cancer chemoprevention procedure of A.

Whether these studies are found to be really functional, we will have the beginning of a new chemoprevention program with herbal supplements that could have the broadest implications for the well-being of society. Journal reference: Chakraborty T, Bhuniya D, Chatterjee M, Rahaman M, Singha D, Chatterjee BN, Datta S, Rana A, Samanta K, Srivastawa S, Maitra SK, Chatterjee M. Acanthus ilicifolius plant extract prevents DNA alterations in a transplantable Ehrlich ascites carcinoma-bearing murine model.

Universe J Gastroenterol 2007; 13(48): 6538-6548 http: 1007-9327 13 6538.asp Adapted from fabric provided by World Journal of Gastroenterology, via EurekAlert!, AAAS. Mail to a friend Print Article Permanent link: 1515 1 Leaf-extract-Of-Indian-Plant-Could-be-Effective-in-Preventing-Hepatic-Cancer Comments No Comments Found.

From http://topcancernews.com/news/1515/1/leaf-extract-of-indian-~

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They identified 14 randomised control trials that compared the effects of adding hawthorn draw forth or placebo to conventional therapies. The proof involved a total of 855 patients and the data indicated that hawthorn extract: A few people reported gentle nausea, dizziness and heart and stomach complaints.

There is good basis that, when used alongside conventional therapy, hawthorn pluck can bring additional benefits," states lead researcher Dr Ruoling Guo, who works in Complementary Medicine at Peninsula Medical School at the Universities of Exeter and Plymouth, UK.

If I had chronic heart failure, I certainly would deal with (using) it," said review co-author Dr. Max Pittler, deputy director of complementary medicament at Peninsula Medical School in Exeter, England.

The audit does not include results of a large new study -- unpublished to date -- that suggested hawthorn has only a local affect on lifespan. At issue is heart failure, a common condition that is both debilitating and deadly. An estimated five million Americans suffer from passion failure, which is often the result of clogged arteries that put stress on the affection by forcing it to attempt harder.

As a result, the heart becomes larger while failing to effectively move blood around the body. This causes liquor to build up in the legs and lungs, often causing shortness of breath and other symptoms.

Perhaps the most famous heart remissness patient is Vise President Dick Cheney, who has suffered from a long history of cardiac problems and has a defibrillator implanted in his chest.

According to the new review, the hawthorn bush turn out single of the most commonly used herbal prescription in the United States.

Assorted believe that hawthorn extract improves heart health, lowers cholesterol and boosts antioxidant levels.

To determine whether hawthorn is indeed an effective treatment, Pittler and team-mate searched the medical literature for high-quality studies into the apply of the herb in long-lasting heart non-performance patients.

The check of the studies appears in the latest issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that assess medical research. Systematic reviews like this one draw evidence-based conclusions about medical practice after considering both the content and quality of existing medical testing on a topic.

The researchers found 14 studies that met their criteria, many of which looked at the use of hawthorn as an addition to conventional medications. The display authors combined the results of 10 studies of 855 patients into a meta-analysis.

Compared to placebo, hawthorn extract boosted the maximum level of physiological workload -- a fact that the review authors described as significant, although they acknowledged they based the finding on cramped numbers of studies and patients. The analysis found that hawthorn, as compared to placebo, also decreased the "pressure-heart rate product," a measurement of how much oxygen is used by the heart.

In addition, the analysis article that two other measurements -- exercise tolerance, and shortness of breath and fatigue -- improved "significantly" in patients who used hawthorn.

Side conclusion were reported to be "infrequent, mild and transient," and included nausea, dizziness and emotions and gastrointestinal complaints. The studies reviewed did not examine death rates in detail, however. Overall, the review showed a "significant benefit in symptom control and physiologic outcomes" in patients who took hawthorn, Pittler said.

According to him, the extract materialize to boost the strength of feelings contractions, increase blood flow through arteries and reduce bumpy heartbeats.

From http://sciencedaily.com/releases/2008/01/080122203321.htm