The researchers also recommend that documentation of supplement usage be reformed part of routine health assessments championing all patients, particularly cancer patients.

Md entail to ask their patients not only about the prescription drugs they may be taking, but – perhaps still more importantly – about the over-the-counter drugs and supplements, which may have a profound impact on sure health conditions," said Dr. Claus Roehrborn, chairman of urology at UT Southwestern and one of the study’s authors.

The researchers began their investigation when two patients being seen by UT Southwestern doctors developed aggressive prostate cancer within months of starting daily consumption of the same dietary supplement. Both men purchased the same product, one to develop stronger muscles and enhance sexual performance, the other to gain muscle. Dr.

Roehrborn, Dr. Shahrokh Shariat, a resident in urology and the study’s lead author, and their colleagues analysed the supplement, which is not named in the study.

They found that the product’s label listed element that were not present, misrepresented the concentrations of the ingredients in duration and failed to list all the steroid hormones contained in the product. Hormone discussion revealed that the supplement contained testosterone and estradiol, a sex hormone.

Researchers then tested the effect of the product on human prostate cancer-cell lines. The product proved to be a more potent stimulator of cancer-cell growth than testosterone. Additionally, attempts to stop the cancer-cell advance with increasing concentrations of the anti-cancer drug bicalutamide proved to be futile.

Bicalutamide is an uttered nonsteroidal anti-androgen hand-me-down to treat prostate cancer," Dr. Shariat said. The fact that this supplement caused the drug to be less effective is very troubling."

Based on the clinical data and cell culture experiments, the researchers filed an adverse event report with the Food and Drug Administration.

The government agency in circle issued a warning letter to the manufacturers, which led to the emigration of the product from the market. Unlike prescription and over-the-counter drugs, the law does not require nutritional supplements to undergo pre-market approval for safety and efficacy," Dr.

The in fashion FDA regulatory system supplys little oversight or assurances that dietary addition will have foreseeable pharmacological consequence or even that product labels provide accurate information for consumers."

The researchers break silence expanded research is needed to define the mechanism, security and efficacy of common herbal and hormone dietary supplements. For most supplements efficacy is not established in randomized, controlled trials. What is worse, safety is usually equally poorly established," said Dr. Roehrborn, who directs the Sarah M. Charles E. Seay Center for Pediatric Urology.

An estimated 42 percent to 69 percent of U.S. 36;34.4 billion, according to published reports cited in the study. Individuals often utilize supplements because they believe these natural issue are safe and drug-free. The traffic of androgenic steroids is exponentially increasing. In 2004, U.S. 36;425 million.

Accustomed that testosterone supplements are in high demand, there is meaningful concern that supplements, in addition to the single we evaluated, may sit an urgent human health risk," Dr.

Researchers from Baylor College of Medicine in Houston also contributed to the research. Adapted from materials provided next to UT Southwestern Medical Center, via EurekAlert!, AAAS. Drs. Credit: The study, which besides did not find any increased.

15, 2006) - Intakes of dietary or supplemental antioxidants were not associated with a decreased chance of prostate cancer centre of men in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial,.

From http://sciencedaily.com/releases/2008/01/080115085351.htm